Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Abstract The phytosynthesis method was used to prepare ZnO nanoparticles (ZnO NPs) via Senna alata L. leaf extract (SALE) by involving alkaloids, which play an essential role as a source of weak bases during the formation reaction NPs. NPs on glassy carbon electrodes (GCE/ZnO NP) have been introduced investigate its electrochemical activity towards antiretroviral drug, lamivudine (3TC). Several characterization techniques, such Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), and Dynamic Light Scattering (DLS) techniques were employed analyze properties GCE/ZnO As result, in spherical shape showed high purity crystalline hexagonal wurtzite structure with particle diameter 40–60 nm. A Cyclic Voltammetry (CV) measurement confirmed that reduction 3TC exhibited excellent linear range 10–300 µM detection limit 1.902 µM, quantitation 6.330 sensitivity 0.0278 µA/µM. Thus, this research suggests facile for preparation material-based promising drug sensors due their properties.